SNP meeting/IMA PI conference
Constitutive Properties of Biomaterials
University of Pittsburgh
Pittsburgh, PA
September 19 - 21, 2008
Organizers:
David Swigon (swigon@pitt.edu )
Anna Vainchtein (aav4@pitt.edu )
Department of Mathematics, University of Pittsburgh
Sponsors:
National Science Foundation
Institute for Mathematics and its Applications, University of Minnesota
Society for Natural Philosophy
Department of Mathematics,
University of Pittsburgh
Meeting Location:
Frick Fine Arts Building, University of Pittsburgh
Scientific Program:
Mechanics plays an important function in biology at every length scale. On the molecular level, mechanical properties of DNA play an essential role in gene regulation, recombination, and duplication, while protein and RNA deformability influences many biological processes. The mechanics of membranes, microtubules, and filaments is key to the healthy life of a cell. On cellular level, the cytoskeleton remodeling is a vital function of living cells, and variation of mechanical response in the cells is used to detect cell dysfunction. Cell mobility is an essential mechanical component of wound healing mechanisms. At the tissue level, the failures in the response of tissues to stress are at the core of many injuries and diseases, such as bone fractures, aneurysms, etc.
Although continuum biomechanics has already contributed to understanding of human health, diseases, injuries, and their treatment, it has not yet become an integral part of health care delivery. The difficulty stems from the complexity of cell microstructure and organic nature of living materials, which require new theoretical framework for design and interpretation of new classes of experiments. Behavior of biomaterials results from interactions of constituents on multiple length and time scales which cannot be treated by theories developed with traditional materials in mind. In addition, biomaterials have complex geometries and loading conditions that require new computational approaches to solve problems of scientific, industrial and clinical importance. Biomaterials have a complex molecular nature and undergo large deformations which requires the use of nonlinear theories to describe their mechanical behavior. Additional complications stem from the growth, aging, and remodeling capability of living materials that change constitutive properties over time. Approaches have been made both by generalizing classical theory of elasticity and by deriving average properties of structured materials from microscopic and molecular level considerations.
The goal of the meeting is to facilitate interaction between experts in experimental study of biomaterials on one hand and mathematical modeling and nonlinear continuum mechanics on the other. This interaction will promote the exchange of ideas while enabling new interdisciplinary collaborations that will advance understanding of the role of mechanics in biology. Particular emphasis will be placed on characterizing the response of biomaterials at the continuum level within the framework of finite elasticity and related theories, and the development of new theories of mechanics of living matter accounting for growth, aging, and adaptation.
Invited Speakers:
Davide Ambrosi, (Politecnico di Torino)
Bernard Coleman, (Rutgers University)
Stephen Cowin, (City College of NY)
John Criscione, (Texas A&M)
Larry Taber, (Washington University)
Schedule
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September 19, Friday |
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2:20 - 3:00pm |
REGISTRATION |
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3:00 - 3:10pm |
Welcoming address |
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3:10 - 4:10pm |
Bernard Coleman (Rutgers) |
On the often overlooked
importance of charge condensation in cell biology |
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4:10 - 4:30pm |
Coffee break |
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4:30 - 5:00pm |
Shaun Sellers (Washington
U) |
Plasticity-like models for
growth |
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5:00 - 5:30pm |
Thomas Pence (Michigan
State) |
Simple mechanics for treating
swelling in fiber reinforced hyperelastic materials |
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5:30 - 7:00pm |
RECEPTION |
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September 20, Saturday |
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8:30 - 9:00am |
REGISTRATION |
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9:00 - 10:00am |
Steven Cowin (CUNY) |
On the modeling of biological
growth |
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10:00 - 10:20am |
Coffee break |
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10:20 - 11:20am |
Larry Taber (Washington U) |
On a Fundamental Principle for
Morphomechanics |
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11:20 - 11:40am |
Coffee break |
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11:40 - 12:10pm |
Dirk Hartmann (U of
Heidelberg) |
Multiscale Techniques for Biomaterials (abstract) |
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12:10 - 12:40pm |
James Wang (U of
Pittsburgh) |
Experimental Cell Mechanobiology: The Need for Theoretical Modeling (abstract) |
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12:40 - 2:00pm |
LUNCH |
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2:00 - 3:10pm |
Roger Fosdick (U of Minnesota) TRUESDELL LECTURER |
Continuum Thermodynamics from
the Prespective of Invariance |
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3:10 - 3:30pm |
Coffee break |
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3:30 - 4:00pm |
Tim Healey (Cornell) |
Continuum Shell Models for Two-Phase Lipid Bi-layer Membrane Vesicles (abstract) |
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4:00 - 4:30pm |
Ashutosh Agrawal (UC
Berkeley) |
Modeling biomembranes with bending elasticity (abstract) |
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4:30 - 5:30pm |
Future directions discussion |
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6:30 - 9:30pm |
DINNER BANQUET (Holiday Inn, Oakland Room) |
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9:30pm - 10:30pm |
SNP Business Meeting (Thackeray Hall 704) |
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September 21, Sunday |
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9:00 - 10:00am |
John Criscione (Texas
A&M) |
Failures and Future Directions
of Phenomenological Relations for Biological Tissues (abstract) |
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10:00 - 10:20am |
Coffee break |
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10:20 - 11:20am |
Davide Ambrosi (Politecnico
di Torino) |
The insight of mixture theory
for the growth and remodelling of soft biological tissues (abstract) |
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11:20 - 11:40am |
Coffee break |
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11:40 - 12:10pm |
Yongcheng Zhou (UCSD) |
Continuum Modeling of
Electrostatic Induced Macromolecular Deformation |
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12:10 - 12:40pm |
Kai-Bin Fu (Texas A&M) |
The modeling of retinal
ganglion cell (RGC) axons and its convexity
properties (abstract) |
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12:40 - 12:50pm |
Closing remarks |
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Registration:
The registration fee for SNP non-members is $25, which also provides a
one year membership with the Society for
Natural Philosophy. This fee is
waived for students. For participants attending the banquet an additional fee
of $50 will be charged to help cover the costs. All prospective participants
(especially if they plan to attend the banquet) are urged to notify Professor
David Swigon(swigon@pitt.edu).
Travel Support:
Faculty members, students, and employees of IMA Participating Institutions are eligible to apply for travel support from the IMA PI funds of their home institution. Those interested should direct enquiries to IMA directly or to the IMA representative of their home institution.
Accommodations:
Blocks of rooms has been reserved at:
Wyndham Pittsburgh University Place
Hotel, 3454 Forbes Ave., Pittsburgh, tel: 412-683-2040 for $139 a night,
and
Quality
Inn University Center, 3401 Blvd. of the Allies, Pittsburgh, tel:
412-683-6100 or 800-245-4444 for $89 a night (reservations must be made over the
phone using the group name SNP meeting)
In both hotels, rooms must be
reserved by August 19, 2008 to take advantage of the reduced rates.
Transportation:
Public transportation provides a convenient way to reach both hotels from the airport. The Airport Flyer 28X departs every 25-30 minutes from Lower level (baggage claim) door 6, the trip to Oakland Campus takes 50 mins. The bus runs along the Fifth Ave. More information can be found here.
Parking:
Parking meters can be found on Schenley Drive outside the Frick Fine Arts Building. A more economical way is to park at Soldiers and Sailors underground parking garage, next to Thackeray Hall (see below). U Pitt parking map can be found here.
The locations of the hotels and the Frick Fine Arts Building (meeting location) are shown on the map of Oakland Campus of the University of Pittsburgh below; all are within walking distance from each other.
(Click on the map to get a larger picture)