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Post synaptic behavior

Given that a certain amount of transmitter is released from the synaptic terminal, we want to now model the current that appears in the postsynaptic site. To do this we need to model s(t), the fraction of open channels open due to the transmitter T. The typical way to model these is via a series of reactions or so called Markov models in which the probability of channels opening and closing is described by a series of rate constants. This kind of detail is well beyond what one wants for simple modeling, thus, instead, we will describe a couple of simple models for the 4 primary types of postsynaptic response induced by the two principle neurotransmitters.

G. Bard Ermentrout